Journal article
Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1
DJ Martino, S Ashley, J Koplin, J Ellis, R Saffery, SC Dharmage, L Gurrin, MC Matheson, B Kalb, I Marenholz, K Beyer, YA Lee, X Hong, X Wang, D Vukcevic, A Motyer, S Leslie, KJ Allen, MAR Ferreira
Clinical and Experimental Allergy | WILEY | Published : 2017
DOI: 10.1111/cea.12863
Abstract
Background: Genetic variants for IgE-mediated peanut allergy are yet to be fully characterized and to date only one genomewide association study (GWAS) has been published. Objective: To identify genetic variants associated with challenge-proven peanut allergy. Methods: We carried out a GWAS comparing 73 infants with challenge-proven IgE-mediated peanut allergy against 148 non-allergic infants (all ~ 1 year old). We tested a total of 3.8 million single nucleotide polymorphisms, as well as imputed HLA alleles and amino acids. Replication was assessed by de novo genotyping in a panel of additional 117 cases and 380 controls, and in silico testing in two independent GWAS cohorts. Results: We ide..
View full abstractGrants
Awarded by U.S. Department of Defense
Funding Acknowledgements
The genomewide association in this study was funded by the US Department of Defense (grant # W81XWH10-1-0487). The HealthNuts cohort is funded by the Australian National Health and Medical Research Council. This work was supported by the Australian National Health and Medical Research Council (NHMRC), Career Development Fellowship ID 1053756 (SL) Australian Research Council Future Fellowship ID FT120100253 (E), Early Career Fellowships 1072752, 1054592 (DM, JE) and the Victorian Life Sciences Computation Initiative (VLSCI) grant number VR0240 on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government, Australia (SL). Research at the Murdoch Childrens Research Institute was supported by the Victorian Government's Operational Infrastructure Support Program. SL is a partner in Peptide Groove LLP. The UFA study was supported by a Clinical Exchange Program fellowship of the Experimental and Clinical Research Center of Max-Delbruck-Center and Charite Medical School. We thank Markus M Noethen (Institute of Human Genetics, University of Bonn, Germany) and Sven Cichon (Division of Medical Genetics, University Hospital Basel and Department of Biomedicine, University of Basel) for providing genotype data of the Heinz Nixdorf RECALL (HNR) study.